mgus {survival} | R Documentation

## Monoclonal gammapothy data

### Description

Natural history of 241 subjects with monoclonal gammapothy of undetermined significance (MGUS).

### Usage

    mgus
    mgus1
    mgus2

### Format

mgus: A data frame with 241 observations on the following 12 variables.

id: | subject id
age: | age in years
sex: | `male` or `female`
dxyr: | year of diagnosis
pcdx: | for subjects who progress to a plasma cell malignancy
| the subtype of malignancy: multiple myeloma (MM) is the
| most common, followed by amyloidosis (AM), macroglobulinemia (MA),
| and other lymphprolifative (LP)
pctime: | days from MGUS until diagnosis of a plasma cell malignancy
futime: | days from diagnosis to last follow-up
death: | 1= follow-up is until death
alb: | albumin level at MGUS diagnosis
creat: | creatinine at MGUS diagnosis
hgb: | hemoglobin at MGUS diagnosis
mspike: | size of the monoclonal protien spike at diagnosis

mgus1: The same data set in start,stop format. Contains the id, age, sex, and laboratory variable described above along with

start, stop: | sequential intervals of time for each subject
status: | =1 if the interval ends in an event
event: | the event type

mgus2: The mgus data, but formatted in the competing risks style. Each subject has three observations, one for time to death, one for time to MM, and one for time to a PC malignancy other than MM. Contains the id, age, sex, and laboratory variable described above along with

time: | time to event or censoring
status: | 1 if the event occured, 0 otherwise
event: | death, myeloma, or other

### Details

Plasma cells are responsible for manufacturing immunoglobulins, an important part of the immune defense. At any given time there are estimated to be about 10^6 different immunoglobulins in the circulation at any one time. When a patient has a plasma cell malignancy the distribuion will become dominated by a single isotype, the product of the malignant clone, visible as a spike on a serum protein electrophoresis. Monoclonal gammapothy of undertermined significance (MGUS) is the presence of such a spike, but in a patient with no evidence of overt malignancy. This data set of 241 sequential subjects at Mayo Clinic was the groundbreaking study defining the natural history of such subjects.

### Source

Mayo Clinic data courtesy of Dr. Robert Kyle.

### References

R Kyle, Benign monoclonal gammopathy – after 20 to 35 years of follow-up, Mayo Clinic Proc 1993; 68:26-36.

[Package survival version 2.36-14 Index]